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It preserves natural pulsatile GH release and requires more frequent administration

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Device manufacturers mark the insulin syringes in units (U-100 is the most common for 100 units of insulin per mL) , making them suitable for individuals requiring ongoing insulin therapy

Hyperglycaemia further contributes to membrane rigidity through the generation of AGEs, which aggravate oxidative stress and promote free radical formation, causing damage to the lipid bilayer (52)

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